Abstract Background The incidence of synchronous gastrointestinal neuroendocrine tumors (GI-NETs) and colorectal cancer is very low.Case presentation We present a 72-year-old man diagnosed with a rectal neuroendocrine tumor (NET) with multiple organ metastases and simultaneous sigmoid colon cancer.Although the NET was his prognostic factor, he unde
A platform trial approach to proof-of-concept (POC) studies in autism spectrum disorder: Autism spectrum POC initiative (ASPI)
Background: Over the past decade, autism spectrum disorder (ASD) research has blossomed, and multiple clinical trials have tested potential interventions, with varying results and no clear demonstration of efficacy.Lack of clarity concerning appropriate biological mechanisms to target and lack of sensitive, objective tools to identify subgroups and
Breast Cancer Treatment in the Era of Precision Medicine
Breast cancer is the most common cancer in women in the Western world.Treatment decisions in the adjuvant and metastatic setting are based on three immunohistochemistry markers, namely estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).Based on the St.Gallen consensus, four distinct subtypes are
COMPILE-TIME FUNCTION CALL INTERCEPTION FOR TESTING IN C/C++
In C/C++, during the test development process we often have to modify the public interface of a class to replace existing dependencies; supplementary setter or constructor functions or extra template parameters are added for dependency injection.These solutions may have serious detrimental effects on the code structure Collections and sometimes on
Collection of human and environmental data on pesticide use in Europe and Argentina: Field study protocol for the SPRINT project.
Current farm systems rely on the use of Plant Protection Products (PPP) Baby Pants to secure high productivity and control threats to the quality of the crops.However, PPP use may have considerable impacts on human health and the environment.A study protocol is presented aiming to determine the occurrence and levels of PPP residues in plants (crops